amikacin sulfate
amikacin sulfate
CAS: 149022-22-0
Molecular Formula: C22H45N5O17S
amikacin sulfate - Names and Identifiers
| Name | amikacin sulfate |
| Synonyms | AMIKASIN SULFATE liusuanamukaxonm amikacin sulfate Amikacin Sulfate Salt Amikacin sulfate salt mikacin disulfate salt AMIKACIN SULFATE SALT, AMINOGLYCOSID (2R)-4-amino-N-{(1R,2S,3S,4R,5S)-5-amino-2-[(3-amino-3-deoxy-α-D-glucopyranosyl)oxy]-4-[(6-amino-6-deoxy-α-D-glucopyranosyl)oxy]-3-hydroxycyclohexyl}-2-hydroxybutanamide sulfate (salt) |
| CAS | 149022-22-0 |
| EINECS | 254-648-6 |
| InChI | InChI=1/C22H43N5O13.H2O4S/c23-2-1-8(29)20(36)27-7-3-6(25)18(39-22-16(34)15(33)13(31)9(4-24)37-22)17(35)19(7)40-21-14(32)11(26)12(30)10(5-28)38-21;1-5(2,3)4/h6-19,21-22,28-35H,1-5,23-26H2,(H,27,36);(H2,1,2,3,4)/t6-,7+,8+,9+,10+,11-,12+,13+,14+,15-,16+,17-,18+,19-,21+,22+;/m0./s1 |
| InChIKey | HIBICIOPDUTNRR-BOEHXBESSA-N |
amikacin sulfate - Physico-chemical Properties
| Molecular Formula | C22H45N5O17S |
| Molar Mass | 683.68 |
| Melting Point | 220-230℃ |
| Boling Point | 1102.4°C at 760 mmHg |
| Flash Point | 620.5°C |
| Solubility | Soluble in water (50 mg/ml), DMSO (<1 mg/ml at 25 °C), and ethanol (<1 mg/ml at 25 |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | solid |
| Color | white to off-white |
| Storage Condition | Inert atmosphere,2-8°C |
| MDL | MFCD00167475 |
| Use | Anti-Infective Drugs for the treatment of urinary tract infections caused by sensitive bacteria, sepsis, skin infections, bone and joint infections, Pneumonia and lower respiratory tract infections |
| In vitro study | Amikacin offers definite advantages for treating infections caused by organisms resistant to other aminoglycosides. Amikaci is affected by relatively few arninoglycoside-modifying enzymes. Amikacin is useful in the treatment of infections caused by Nocardia asteroides , Mycobacterium avium-intracellulare , and certain species of "rapid-growing" mycobacteria (that is, M. chelonae and M. fortuitumi ). Amikacin (100-1500 μM) causes a reliable dose-dependent loss of lateral line zebrafish hair cells with a LD 50 value of 453 μM. |
amikacin sulfate - Risk and Safety
| WGK Germany | 2 |
| RTECS | WK1961200 |
amikacin sulfate - Upstream Downstream Industry
| Raw Materials | Acetone Sulfuric acid |
amikacin sulfate - Reference
| Reference Show more | 1. Gao Mingkun, Zhang Zhi, Qian Fang. Toxicology, Functional Test and Effect of Mixed Bacterial Preparation (BMX) on Fattening Pigs [J]. Feed Research, 2018, No.485(04):66-71. 2. Liu Minfang, Cao Mengrui, Li Rongxu, et al. Isolation, Identification and Drug Sensitivity Analysis of Waterfowl-derived Salmonella in Some Areas of Guangdong [J]. Heilongjiang Animal Husbandry and Veterinary Medicine, 2018(10). 3. Zhang Jipei, Wei Qinglan, Tan Hualong, et al. Study on drug resistance and aminoglycoside resistance genes of Escherichia coli from waterfowl in Guangdong [J]. Advances in Animal Medicine, 2016, 37(005):42-46. 4. Wei Qinglan, Zhang Jipei, Ren Tao, drug sensitivity analysis of waterfowl-derived Escherichia coli in Guangdong [J]. Heilongjiang Animal Husbandry and Veterinary Medicine, 2015, 000(012):180-181. 5. [IF = 7.514] Ximo Wang et al."A novel SERS sensor for the ultrasensitive detection of kanamycin based on a Zn-doped carbon quantum dot catalytic switch controlled by nucleic acid aptamer and size-controlled gold nanorods." Food Chem. 2021 Nov;362:130261 6. [IF = 2.281] Zhiqiang Zhang et al."Contribution of the colicin receptor CirA to biofilm formation, antibotic resistance, and pathogenicity of Salmonella Enteritidis." J Basic Microb. 2020 Jan;60(1):72-81 |
amikacin sulfate - Reference Information
| Biological activity | Amikacin sulfate (BAY 41-6551 sulfate) is an aminoglycoside antibiotic and a semi-synthetic analog of kanamycin. Amikacin sulfate has a bactericidal effect and directly acts on the ribosomal subunits of 30S and 50S bacteria to inhibit protein synthesis. Amikacin sulfate is very effective against most Gram-negative bacteria (Gram-negative bacteria), including gentamicin and tobramycin resistant strains. Amikacin sulfate also inhibit infections caused by Noca susceptible and non-tuberculous mycobacteria. |
| Animal Model: | Male Fischer 344 rats (40-50-day-old) |
| Dosage: | 320 mg/kg |
| Administration: | Subcutaneous injection; daily; for 10 days |
| Result: | Induced hearing loss in rats. |
| use | anti-infective drugs are used to treat urinary tract infection, septicemia, skin infection, bone and joint infection, pneumonia and lower respiratory tract infection caused by sensitive bacteria |
Last Update：2024-04-10 22:29:15
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Raw Materials for amikacin sulfate